He was married to Nancy Elizabeth Bender (daughter of Isaac Bender and Rebecca or Elizabeth Williams) in Nov 1868 in Braxton Co., WV.  Nancy Elizabeth Bender was born between 1841 and 1847 in VA.  She appeared on the census in 1870 in Fork Lick District, Webster Co., WV.  She appeared on the census in 1880 in Otter District, Braxton Co., WV.  John Eldridge Eakle and Nancy Elizabeth Bender had the following children:
 

• George Eakle was born in 1869.  He appeared on the census in 1870 in Fork Lick District, Webster Co., WV.
• Branty Cletus Eakle was born on 29 Dec 1870 in WV.  He appeared on the census in 1880 in Otter District, Braxton Co., WV.  He died on 30 Jun 1965.
• Wilbur H. Eakle was born in 1873 in WV.  He appeared on the census in 1880 in Otter District, Braxton Co., WV.
• Osker Eakle was born in 1874 in WV.  He appeared on the census in 1880 in Otter District, Braxton Co., WV.
• Columbus Eakle was born in 1878 in WV.  He appeared on the census in 1880 in Otter District, Braxton Co., WV.
• Laurie Eakle appeared on the census in 1880 in Otter District, Braxton Co., WV.  She was born in Jan 1880 in WV.