1657 - Boston Measles
1687 - Boston Measles
1690 - New York Yellow Fever
1713 - Boston Measles
1729 - Boston Measles
1732-3 Worldwide Influenza
1738 - South Caroline Small pox
1739-40 Boston Measles
1747 - CT,NY,PA,SC Measles
1759 - N. America [areas inhabited by white people] Measles
1761 - North America and West Indies Influenza
1772 - North America Measles
1775 - North America [especially hard in the NE] epidemic Unknown
1775-6 Worldwide [one of the worst epidemics] influenza
1783 - Dover DE ["extremely fatal"] Bilious Disorder
1788 - Philadelphia and New York Measles
1793 - Vermont [a "putid fever"] and influenza
1793 - VA [killed 500 in 5 counties in 4 weeks] Influenza
1793 - Philadelphia [one of the worst epidemics] Yellow fever
1793 - Harrisburg, PA [many unexplained deaths] Unknown
1793 - Middletown, PA. [many mysterious deaths] Unknown
1794 - Philadelphia, PA Yellow fever
1796-7 - Philadelphia, PA Yellow Fever
1798 - Philadelphia, PA [one of the worst] Yellow Fever
1803 - New York Yellow Fever
1820-3 Nationwide [starts Schuylkill River and spreads] "Fever"
1831-2 Nationwide [brought by English emigrants] Asiatic Cholera
1832 - NY City and other major cities Cholera
1837 - Philadelphia Typhus
1841 - Nationwide [especially severe in the south] Yellow Fever
1847 - New Orleans Yellow Fever
1847-8 Worldwide Influenza
1848-9 North America Cholera
1850 - Nationwide Yellow Fever
1850-1 North America Influenza
1852 - Nationwide [New Orleans-8,000 die in summer] Yellow Fever
1855 - Nationwide [many parts] Yellow Fever
1857-9 Worldwide [one of the greatest epidemics] Influenza
1860-1 Pennsylvania Small Pox
1865-73 - Philadelphia, NY, Boston, New Orleans] [Small Pox Baltimore, Memphis, Washington D.C.] [Cholera [A series of recurring epidemics of: Typhus, Typhoid, Scarlet Fever, Yellow Fever
1873-5 - North America and Europe Influenza
1878 - New Orleans [last great epidemic] Yellow Fever
1885 - Plymouth, PA Typhoid
1886 - Jacksonville, FL Yellow Fever
1918 - Worldwide - more people were hospitalized with influenza in WWI from this epidemic than wounds. US Army training camps became death camps, with 80% death rate in some camps
Finally these specific instances of cholera were mentioned:
1833 - Columbus, OH
1834 - New York City
1849 - New York
1851 - Coles Co., IL, The Great Plains and Missouri