State College is the largest borough in Centre County in the U.S. state of Pennsylvania. It is the principal city of the State College, Pennsylvania Metropolitan Statistical Area which encompasses all of Centre county. As of the 2000 census, the borough population was 38,420 (estimated 38,720 in 2007) and roughly double that total lived in the borough plus the surrounding townships. Of that population, 20,011 or 52.1% are males and 18,409 or 47.9% are females.

The town is dominated economically and demographically by the presence of the main campus of the Pennsylvania State University, colloquially referred to as Penn State. "Happy Valley" is an often-used term to refer to the State College area, including the borough and the townships of College, Harris, Patton, and Ferguson. In 2008, State College was ranked as the second safest metropolitan area in the United States by the CQ Press and ranked safest in 2009. State College is located at 40° 47' 29"N 77° 51' 31"W. The elevation is approximately 1,200 feet above sea level. According to the United States Census Bureau, the borough has a total area of 4.5 square miles, all of it land.

State College evolved from village to town to serve the needs of the fledgling Pennsylvania State College, founded as the Farmers' High School of Pennsylvania in 1855. Since then, the school has grown into a major university, renamed in 1953 The Pennsylvania State University. State College was incorporated as a borough on August 29, 1896 and has since grown with the university, sharing a symbiotic relationship. In 1973 State College adopted a home rule charter which took effect in 1976. The areas outside of State College are filled with historic towns and villages, immense tracts of farmland, and an expanse of mountains and forests.

The university has a post office address of University Park, Pennsylvania, which is sometimes a cause for confusion. When Penn State changed its name from College to University in 1953, its president, Milton S. Eisenhower, sought to persuade the town to change its name as well. A referendum failed to yield a majority for any of the choices for a new name, and so the town remains State College. After this, Penn State requested a new name for its on-campus post office in the Hetzel Union Building from the U.S. Post Office Department. The post office, which has since moved across a street to the McAllister Building, is the official home of zip code 16802 (University Park).