1Dr. Charles Banks, compiler, The History of Martha's Vineyard, Family Genealogies, Vol. III, p. 71 (1925).
URL = http://history.vineyard.net/chase.htm This shows that all of Isaac Chase's children were through his second wife Mary Tilton.
" THE CHASE FAMILY
12. ISAAC CHASE, (Thomas1), the first of the name to settle on Martha's Vineyard, was descended from the Chase family of the parish of Chesham, Buckinghamshire, through Aquila, (a) his grandfather, bapt. 14 Aug. 1580. Richard,(b) his great grand-father, bapt. 23 Aug. 1542 (who m. Joan Bishop 16 May 1564) and Thomas (c). Isaac2 was b. abt. 1 Apr. 1650, or 1647 (according to his gravestone), and came first to Tisbury in 1674 bringing with him the trade of a blacksmith as well as his predilections for the Quaker religion.
He m. (1) MARY PERKINS of Hampton, N. H. (sister of his fellow emigrant to the Vineyard, Jacob Perkins) 20 Feb. 1673, by whom he had no issue. She d. soon after and he m. (2) MARY TILTON (sister of another fellow emigrant, Samuel Tilton (3) 5 Oct. 1675, the ceremony being performed by Rev. John Mayhew. She was b. 1658-9 and d. 14 June 1746 being the mother of all his children. His Will 12 Feb. 1721-22 was pro. July 1727, and his large landed estate, comprising nearly the whole of the present village of Vineyard Haven, became an inheritance for his children.
20. THOMAS, b. 9 Nov. 1677. 21. RACHEL, b. 25 Oct. 1679; m. (1) SAMUEL KNIGHT (20) of Charlestown 19 July 1700; (2) SAMUEL MUNKLEY after 1721. 22. ISAAC, b. 21 Jan. 1681. 23. ABRAHAM, b. 10 Jan. 1683. 24. JAMES, b. 15 Jan. 1685. 25. MARY, b. 17 Jan. 1687; m. BENJAMIN WEEKS (16) 14 Jan. 1704. 26. JOSEPH, b. 26 Feb. 1689. 27. JONATHAN, b. 28 Dec. 1691. 28. HANNAH, b. 25 Nov.1693; m. NATHAN PEASE (120) 30 Oct. 1712. 29. SARAH, b. 15 Oct. 1695; m. SAMUEL COBB 27 June 1716. 30. PRISCILLA, b. 12 Nov. 1697; m. NATHAN FOLGER 18 Nov. 1718. 31. ELIZABETH, b. 7 Sept. 1703; d. 27 Sept. 1719 unm."