History of Bourbon, Scott, Harrison and Nicholas Counties, Kentucky, ed.
by William Henry Perrin,  O. L. Baskin & Co., Chicago, 1882.  p. 508.
[Bourbon County]  [Millersburg Precinct]

ISAAC R. BEST, physician, P. O. Millersburg; son of Abner O. and Louisa
(Reynolds) Best; she, a daughter of Isaac Reynolds, who was born Jan. 1,
1792, and at an early day one of the most prominent shippers by flat
boat from Augusta, Ky., to New Orleans, the return trip being made on
foot.  Abner O. was a son of James and Sally (Overfield) Best, who were
among the earliest and most prominent families of Mason County; they
had five sons and one daughter, who is the wife of Joseph A. Miller (see
sketch); the sons were Thomas L., a farmer and tobacco merchant, of Mason
County, the subject of this sketch; Benj. Desha, a merchant, resides at
Covington; George R. and William H., farmers, in Mason County.  Dr. Best
was born Jan. 15, 1840; received a classical education, graduating from
Center College, with high honors, in 1860; was, while there, a member of
Epsilon Chapter, Beta Theta Phi fraternity.  Soon after receiving his
literary education, he entered the Medical Department of the University
of Pennsylvania, graduating therefrom in 1865, when he immediately
engaged in the practice of his profession, at Augusta, Ky., thence to
Washington, where he remained until July, 1870, when he sought his
present location, where he has built up a large and lucrative practice
by his diligence and ability in the profession.  He was married to
Sally Barbee, daughter of Thomas and Nancy (Fry) Barbee; she a native
of Danville, Ky., and sister to Gen. Fry, who was prominent in military
circles during the late war.  Thomas Barbee, Sr., was an officer in the
Revolutionary war.  By this marriage there were five sons--Thomas R.,
Arthur S., Spencer B., Isaac D., and Harry M.  The Doctor is a member
of the Masonic Order, and, with his wife, connected with the Church.

Best Reynolds Overfield Miller Barbee Fry
=
Mason-KY Kenton-KY Boyle-KY PA

http://www.rootsweb.com/~kygenweb/kybiog/bourbon/best.ir.txt